Description
DMOAD Actions
The PPS in CARTROPHEN VET has been shown to exhibit the following actions:
- Improve the quality of cartilage – Stimulates chondrocytes to synthesize cartilage matrix
- Improves the quantity and quality of synovial fluid – Stimulates synoviocyte biosynthesis of hyaluronan, improving both the quantity and molecular weight
- Reduces the levels of cartilage degrading enzymes – Metalloproteinase (as collagenase) and elastase are significantly reduced and tissue inhibitor of metalloproteinase (TIMP) is increased
- Stimulates stem cell activity and cartilage cell differentiation – Promotes mesenchymal precursor cell (MPC) proliferation and cartilage cell differentiation. Importantly, the frequency of MPCs is elevated in OA cartilage
- Increased blood supply and nutrition to the joint and subchondral bone – Mobilizes thrombi and fibrin deposits, lipids and cholesterol in both synovial tissues and subchondral blood vessels
- Strong anti-inflammatory properties – The potent anti-inflammatory activities of PPS have been consistently demonstrated in different models of severe inflammation
- Eliminates free radicals – Stimulates the release of the free radical scavenging enzyme, superoxide dismutase (SOD)
- Stimulates important growth factors that promote cartilage growth – Increases the production of the essential trophic factor for cartilage, insulin- like growth factor-1 (IGF-1)11, which stimulates incorporation of sulfate and encourages cartilage growth
- Affinity for cartilage –The strong binding of the drug to cartilage protein results in therapeutic concentrations for 4 days
